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Theranostic Nanomedicine for Malignant Gliomas.

ABSTRACT: Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, represents a strategic tool for the management of malignant brain tumors, allowing for the detection of therapies that are specific to the single patient and avoiding overdosing the non-responders. Here, recent theranostic nanomedicine approaches for glioma therapy are described.

SUBMITTER: d'Angelo M

PROVIDER: S-EPMC6868071 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Theranostic Nanomedicine for Malignant Gliomas.

d'Angelo Michele M Castelli Vanessa V Benedetti Elisabetta E Antonosante Andrea A Catanesi Mariano M Dominguez-Benot Reyes R Pitari Giuseppina G Ippoliti Rodolfo R Cimini Annamaria A

Frontiers in bioengineering and biotechnology 20191114

Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, repr ...[more]

PMID: 31799246

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