Ontology highlight
ABSTRACT:
SUBMITTER: Lu X
PROVIDER: S-EPMC6868394 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Lu Xiaopeng X Tang Ming M Zhu Qian Q Yang Qiaoyan Q Li Zhiming Z Bao Yantao Y Liu Ge G Hou Tianyun T Lv Yafei Y Zhao Ying Y Wang Haiying H Yang Yang Y Cheng Zhongyi Z Wen He H Liu Baohua B Xu Xingzhi X Gu Luo L Zhu Wei-Guo WG
Nucleic acids research 20191201 21
The binding of p53-binding protein 1 (53BP1) to damaged chromatin is a critical event in non-homologous DNA end joining (NHEJ)-mediated DNA damage repair. Although several molecular pathways explaining how 53BP1 binds damaged chromatin have been described, the precise underlying mechanisms are still unclear. Here we report that a newly identified H4K16 monomethylation (H4K16me1) mark is involved in 53BP1 binding activity in the DNA damage response (DDR). During the DDR, H4K16me1 rapidly increase ...[more]