Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6874898 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Wang Yujia Y Dix Melissa M MM Bianco Giulia G Remsberg Jarrett R JR Lee Hsin-Yu HY Kalocsay Marian M Gygi Steven P SP Forli Stefano S Vite Gregory G Lawrence R Michael RM Parker Christopher G CG Cravatt Benjamin F BF
Nature chemistry 20191028 12
A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ligand discovery with chemical proteomics to furnish global portraits of reversible small-molecule/protein interactions in human cells. Excavating clear structure-activity relationships from these 'ligandability' maps, however, was confounded by the distinct physicochemical ...[more]