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A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation.

ABSTRACT: Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (¹H NMR, ¹³C NMR, ¹⁵N NMR and HRMS). Various advantages of reported protocol are the ease of preparation, short reaction times (10 min), aqueous solvent and excellent yields (89-98%). Additionally, this method provides a clean access to the desired products by simple workup.

SUBMITTER: Khumalo MR

PROVIDER: S-EPMC6878704 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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A facile and one-pot synthesis of new tetrahydrobenzo[b]pyrans in water under microwave irradiation.

Khumalo Mandlenkosi Robert MR Maddila Surya Narayana SN Maddila Suresh S Jonnalagadda Sreekantha B SB

BMC chemistry 20191126 1

Eleven new tetrahydrobenzo[b]pyran derivatives were synthesized via a three component reaction of different aromatic aldehydes, methyl cyanoacetate and 1,3-cyclohexadione, with water as solvent under catalyst-free microwave irradiation. The structures of all the new molecules were well analysed and their structures established by using various spectral techniques (1H NMR, 13C NMR, 15N NMR and HRMS). Various advantages of reported protocol are the ease of preparat ...[more]

PMID: 31788672

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