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Acquisition of class C ?-lactamase PAC-1 by ST664 strains of Pseudomonas aeruginosa.

ABSTRACT: Four ST664 (serotype O:5) strains of Pseudomonas aeruginosa highly resistant to antibiotics including ceftolozane/tazobactam and ceftazidime/avibactam but susceptible to colistin, were found to harbor the rare class C ?-lactamase PAC-1 encoding gene on a chromosomally-located Tn1721-like transposon. Gene bla PAC-1 was associated with the 16S rRNA methylase determinant rmtF2, that confers pan-aminoglycoside resistance. These genotypically-related strains were isolated in repatriated patients from Mauricius and Afghanistan and close to a lineage reported in Nepal, Pakistan and India.

SUBMITTER: Bour M

PROVIDER: S-EPMC6879236 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Acquisition of class C β-lactamase PAC-1 by ST664 strains of Pseudomonas aeruginosa.

Bour Maxime M Fournier Damien D Jové Thomas T Pouzol Armelle A Miltgen Guillaume G Janvier Frédéric F Jeannot Katy K Plésiat Patrick P

Antimicrobial agents and chemotherapy 20190916 12

Four ST664 (serotype O:5) strains of Pseudomonas aeruginosa highly resistant to antibiotics including ceftolozane/tazobactam and ceftazidime/avibactam but susceptible to colistin, were found to harbor the rare class C β-lactamase PAC-1 encoding gene on a chromosomally-located Tn1721-like transposon. Gene bla PAC-1 was associated with the 16S rRNA methylase determinant rmtF2, that confers pan-aminoglycoside resistance. These genotypically-related strains wer ...[more]

PMID: 31527025

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