Ontology highlight
ABSTRACT:
SUBMITTER: Blank BR
PROVIDER: S-EPMC6880962 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Blank Brian R BR Talukder Poulami P Muir Ryan K RK Green Erin R ER Skaar Eric P EP Renslo Adam R AR
ACS infectious diseases 20190611 8
Iron is essential to all life, and competition for this vital nutrient is central to host-pathogen interactions during infection. The opportunistic Gram-negative pathogen <i>Pseudomonas aeruginosa</i> utilizes a diverse array of iron-acquisition strategies, including those enabling import of extracellular ferrous iron. We hypothesize that soluble and redox-active ferrous iron can be employed to activate caged antibiotics at sites of infection in vivo. Here we describe new chemistry that expands ...[more]