Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC5910837 | biostudies-other | 2018 Apr
REPOSITORIES: biostudies-other
Xu He H Lee Min-Sik MS Tsai Pei-Yun PY Adler Ashley S AS Curry Natasha L NL Challa Saketh S Freinkman Elizaveta E Hitchcock Daniel S DS Copps Kyle D KD White Morris F MF Bronson Roderick T RT Marcotrigiano Michael M Wu Yaotang Y Clish Clary B CB Kalaany Nada Y NY
Proceedings of the National Academy of Sciences of the United States of America 20180402 16
Non-small-cell lung cancer (NSCLC) is a leading cause of cancer death worldwide, with 25% of cases harboring oncogenic Kirsten rat sarcoma (<i>KRAS</i>). Although KRAS direct binding to and activation of PI3K is required for <i>KRAS</i>-driven lung tumorigenesis, the contribution of insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) in the context of mutant <i>KRAS</i> remains controversial. Here, we provide genetic evidence that lung-specific dual ablation of insulin recept ...[more]