Ontology highlight
ABSTRACT:
SUBMITTER: Bobo C
PROVIDER: S-EPMC6888115 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Bobo Claude C Céré Claire C Dufossée Mélody M Dautant Alain A Moreau Violaine V Manon Stéphen S Beaumatin Florian F Priault Muriel M
International journal of molecular sciences 20191108 22
Bcl-x<sub>L</sub> is an oncogene of which the survival functions are finely tuned by post-translational modifications (PTM). Within the Bcl-2 family of proteins, Bcl-x<sub>L</sub> shows unique eligibility to deamidation, a time-related spontaneous reaction. Deamidation is still a largely overlooked PTM due to a lack of easy techniques to monitor Asn→Asp/IsoAsp conversions or Glu→Gln conversions. Being able to detect PTMs is essential to achieve a comprehensive description of all the regulatory m ...[more]