Ontology highlight
ABSTRACT:
SUBMITTER: Yang RM
PROVIDER: S-EPMC6888875 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Yang Rui Meng RM Tao Jiong J Zhan Ming M Yuan Hao H Wang Hai Hong HH Chen Sai Juan SJ Chen Zhu Z de Thé Hugues H Zhou Jun J Guo Ying Y Zhu Jun J
Cell death and differentiation 20190301 11
TAMM41, located within the congenital heart diseases (CHD) sensitive region of 3p25 deletion syndrome, is a mitochondrial membrane maintenance protein critical for yeast survival, but its function in higher vertebrates remains unknown. Via in vivo zebrafish model, we found that tamm41 is highly expressed in the developing heart and deficiency of which led to heart valve abnormalities. Molecular mechanistic studies revealed that TAMM41 interacts and modulates the PINK1-PARK2 dependent mitophagy p ...[more]