Ontology highlight
ABSTRACT:
SUBMITTER: Sterk C
PROVIDER: S-EPMC6888954 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sterk Carolin C Gräber Lauren L Schmitz Hans-Peter HP Heinisch Jürgen J JJ
International journal of molecular sciences 20191107 22
The small GTPase Rho5 of <i>Saccharomyces cerevisiae</i> is required for proper regulation of different signaling pathways, which includes the response to cell wall, osmotic, nutrient, and oxidative stress. We here show that proper in vivo function and intracellular distribution of Rho5 depends on its hypervariable region at the carboxyterminal end, which includes the CAAX box for lipid modification, a preceding polybasic region (PBR) carrying a serine residue, and a 98 amino acid-specific inser ...[more]