Ontology highlight
ABSTRACT:
SUBMITTER: Lechner C
PROVIDER: S-EPMC6891749 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20191113 22
Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down syndrome and Alzheimer's disease. Most published inhibitors to date suffer from low selectivity against related kinases or from unfavorable physicochemical properties. In order to identify DYRK1A inhibitors with improved properties, a series of new chemicals based on [<i>b</i>]-annulated halogenated indoles were designed, synt ...[more]