Ontology highlight
ABSTRACT:
SUBMITTER: Thompson B
PROVIDER: S-EPMC6892198 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Human genomics 20191203 1
Retinoic acid (RA) is a potent morphogen required for embryonic development. RA is formed in a multistep process from vitamin A (retinol); RA acts in a paracrine fashion to shape the developing eye and is essential for normal optic vesicle and anterior segment formation. Perturbation in RA-signaling can result in severe ocular developmental diseases-including microphthalmia, anophthalmia, and coloboma. RA-signaling is also essential for embryonic development and life, as indicated by the signifi ...[more]