Ontology highlight
ABSTRACT:
SUBMITTER: Hoyer FF
PROVIDER: S-EPMC6892583 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hoyer Friedrich Felix FF Naxerova Kamila K Schloss Maximilian J MJ Hulsmans Maarten M Nair Anil V AV Dutta Partha P Calcagno David M DM Herisson Fanny F Anzai Atsushi A Sun Yuan Y Wojtkiewicz Gregory G Rohde David D Frodermann Vanessa V Vandoorne Katrien K Courties Gabriel G Iwamoto Yoshiko Y Garris Christopher S CS Williams David L DL Breton Sylvie S Brown Dennis D Whalen Michael M Libby Peter P Pittet Mikael J MJ King Kevin R KR Weissleder Ralph R Swirski Filip K FK Nahrendorf Matthias M
Immunity 20191112 5
Myocardial infarction, stroke, and sepsis trigger systemic inflammation and organism-wide complications that are difficult to manage. Here, we examined the contribution of macrophages residing in vital organs to the systemic response after these injuries. We generated a comprehensive catalog of changes in macrophage number, origin, and gene expression in the heart, brain, liver, kidney, and lung of mice with myocardial infarction, stroke, or sepsis. Predominantly fueled by heightened local proli ...[more]