Ontology highlight
ABSTRACT:
SUBMITTER: Charsar BA
PROVIDER: S-EPMC6894085 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Charsar Brittany A BA Brinton Michael A MA Locke Katherine K Chen Anna Y AY Ghosh Biswarup B Urban Mark W MW Komaravolu Sreeya S Krishnamurthy Karthik K Smit Rupert R Pasinelli Piera P Wright Megan C MC Smith George M GM Lepore Angelo C AC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20191002 12
More than half of spinal cord injury (SCI) cases occur in the cervical region, leading to respiratory dysfunction due to damaged neural circuitry that controls critically important muscles such as the diaphragm. The C3-C5 spinal cord is the location of phrenic motor neurons (PhMNs) that are responsible for diaphragm activation; PhMNs receive bulbospinal excitatory drive predominately from supraspinal neurons of the rostral ventral respiratory group (rVRG). Cervical SCI results in rVRG axon damag ...[more]