Dataset Information

Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.

ABSTRACT: BACKGROUND:Childhood obesity is a major health problem in Mexico. Obesity prevalence estimated by body mass index (BMI) is almost half than that estimated by percent body fat (%BF) in the Childhood Obesity pediatric cohort (COIPIS). OBJECTIVE:We performed a genome-wide association study (GWAS) of BMI and %BF in 828 children from the COIPIS to identify markers of predisposition to high values for both phenotypes used for obesity classification. METHODS:For the GWAS we used the LAT Axiom 1, Affymetrix and 2.5 million single loci from the 1000 Genomes Phase 3 imputation panel. We used a linear model, adjusted by age, sex, and Amerindian ancestry assuming an additive inheritance model. RESULTS:Genome-wide significance (p ? 5.0 × 10-8) and 80% of statistical power was reached for associations of two loci in two genes (CERS3 and CYP2E1) to BMI. Also, 11 loci in six genes (ANKS1B, ARNTL2, KCNS3, LMNB1, SRGAP3, TRPC7) reached genome-wide significance for associations to %BF, though not 80% of statistical power. DISCUSSION:None of the SNPs were previously reported as being associated to BMI or %BF. In addition, different loci were found for BMI and %BF. These results highlight the importance of gaining deeper understanding of genetic markers of predisposition to high values for the phenotypes used for obesity diagnosis.

SUBMITTER: Costa-Urrutia P

PROVIDER: S-EPMC6895864 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.

Costa-Urrutia Paula P Colistro Valentina V Jiménez-Osorio Angélica Saraí AS Cárdenas-Hernández Helios H Solares-Tlapechco Jacqueline J Ramirez-Alcántara Miryam M Granados Julio J Ascencio-Montiel Iván de Jesús IJ Rodríguez-Arellano Martha Eunice ME

Genes 20191119 11

<h4>Background</h4>Childhood obesity is a major health problem in Mexico. Obesity prevalence estimated by body mass index (BMI) is almost half than that estimated by percent body fat (%BF) in the Childhood Obesity pediatric cohort (COIPIS).<h4>Objective</h4>We performed a genome-wide association study (GWAS) of BMI and %BF in 828 children from the COIPIS to identify markers of predisposition to high values for both phenotypes used for obesity classification.<h4>Methods</h4>For the GWAS we used t ...[more]

PMID: 31752434

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Project description:BackgroundObesity is rapidly increasing in Mexican children and adolescents, while food environments are rapidly changing. We evaluated the association between changes in retail food stores and change in body mass index (BMI) in Mexican children and adolescents.MethodsData on 7507 participants aged 5-19 years old came from the Mexican Family Life Survey 2002-2012. Density of food stores at the municipal-level (number of food stores/area in km2) came from the Economic Censuses of 1999, 2004 and 2009. We categorized food stores as small food retail (small neighborhood stores, tiendas de abarrotes in Mexico), specialty foods, fruit/vegetables, convenience foods, and supermarkets. Associations between change in food stores and change in BMI were estimated using five longitudinal linear fixed-effects regression models (one per type of food store) adjusted for age, parental education, municipal-level socioeconomic deprivation and population density. Density of each food store type was operationalized as quartiles. Analyses were stratified by urbanization.ResultsThere was an inverse dose-response association between increases in fruit/vegetable store density and BMI (β = -0.455 kg/m2, β = -0.733 kg/m2, and β = -0.838 kg/m2 in the second, third, and fourth quartile). In non-urban areas, children living in municipalities with the highest density of small food retail stores experienced a reduction in BMI (β = -0.840 kg/m2). In urban areas, there was an inverse association between specialty food stores with BMI (β = -0.789 kg/m2 in third quartile, and β = -1.204 kg/m2 in fourth quartile). We observed dynamic associations with age; results suggested stronger associations in adolescents.ConclusionsThe availability of fruit/vegetable stores may influence a reduction in children and adolescents BMI. These results indicate that policy approaches could be tailored by type of food store - with some consideration for level of urbanization and children's age.

Dataset Information

Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.

Publications

Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.

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