Genome-wide association study of body mass index in subjects with alcohol dependence.

ABSTRACT: Outcomes related to disordered metabolism are common in alcohol dependence (AD). To investigate alterations in the regulation of body mass that occur in the context of AD, we performed a genome-wide association study (GWAS) of body mass index (BMI) in African Americans (AAs) and European Americans (EAs) with AD. Subjects were recruited for genetic studies of AD or drug dependence and evaluated using the Semi-structured Assessment for Drug Dependence and Alcoholism. We investigated a total of 2587 AAs and 2959 EAs with DSM-IV AD diagnosis. In the stage 1 sample (N?=?4137), we observed three genome-wide significant (GWS) single-nucleotide polymorphism associations, rs200889048 (P?=?8.98?*?10-12 ) and rs12490016 (P?=?1.44?*?10-8 ) in EAs and rs1630623 (P?=?5.14?*?10-9 ) in AAs and EAs meta-analyzed. In the stage 2 sample (N?=?1409), we replicated 278, 253 and 168 of the stage 1 suggestive loci (P?

SUBMITTER: Polimanti R 

PROVIDER: S-EPMC5102811 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature