Ontology highlight
ABSTRACT:
SUBMITTER: Han Z
PROVIDER: S-EPMC6896991 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Han Zheng Z Zhang Shuixing S Fujiwara Kenji K Zhang Jia J Li Yuguo Y Liu Jing J van Zijl Peter C M PCM Lu Zheng-Rong ZR Zheng Lei L Liu Guanshu G
Bioconjugate chemistry 20190415 5
A dextran-peptide conjugate was developed for magnetic resonance (MR) molecular imaging of pancreatic ductal adenocarcinoma (PDAC) through its overexpressed microenvironment biomarker, extradomain-B fibronectin (EDB-FN). This new agent consists of diamagnetic and biocompatible dextran and a targeting peptide. Dextrans can be directly detected by chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) without the need for radionuclide or metallic labeling. In addition, large m ...[more]