Discovery of a bone-like blood particle in the peripheral circulation of humans and rodents.

ABSTRACT: OBJECTIVE:To characterize ossified bone marrow blood vessels and confirm the presence of ossified particles (OSP) in humans and rodents. METHODS:Human bone marrow blood vessels were processed for scanning and transmission electron microscopy. Whole blood samples were collected from younger (26-39 years; n = 6) and older (55-63 years; n = 6) volunteers and male Fischer-344 rats (1 month, n = 7; 6 months, n = 7; 12 months, n = 7; 18-months, n = 6; 24 months, n = 8). OSP in the whole blood samples were sorted and imaged with microscopy to determine diameter, circularity, and solidity. Additionally, the chemical composition of OSP was determined via elemental analysis. RESULTS:SEM revealed two types of ossified bone marrow blood vessels: that is, "transitioning" and "ossified." OSP were adhere

SUBMITTER: Prisby R 

PROVIDER: S-EPMC6899169 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature