Ontology highlight
ABSTRACT:
SUBMITTER: Frost GR
PROVIDER: S-EPMC6916654 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frost Georgia R GR Jonas Lauren A LA Li Yue-Ming YM
Frontiers in aging neuroscience 20191210
Alzheimer's disease (AD) is marked by the presence of amyloid beta (Aβ) plaques, neurofibrillary tangles (NFT), neuronal death and synaptic loss, and inflammation in the brain. AD research has, in large part, been dedicated to the understanding of Aβ and NFT deposition as well as to the pharmacological reduction of these hallmarks. However, recent GWAS data indicates neuroinflammation plays a critical role in AD development, thereby redirecting research efforts toward unveiling the complexities ...[more]