Ontology highlight
ABSTRACT:
SUBMITTER: Liu W
PROVIDER: S-EPMC7142236 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Wen W Xu Liyun L Liang Xiaohong X Liu Xiaojun X Zhao Yangbing Y Ma Chunhong C Gao Lifen L
Frontiers in immunology 20200402
T-cell immunoglobulin and mucin domain containing 4 (Tim-4) is a phosphatidylserine receptor and is selectively expressed on antigen presenting cells. Recently, Tim-4 was reported to be expressed on iNKT cells, B1 cells, and tumor cells, suggesting it has multiple biological functions. In this review, we mainly summarize the expression and regulation of Tim-4 in immune cells including T cells, macrophages, dendritic cells, NKT cells, B cells, and mast cells. The expression of Tim-4 in these cell ...[more]