Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery.
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ABSTRACT:
SUBMITTER: Abid Z
PROVIDER: S-EPMC6918296 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery.
Abid Zarmeena Z Dalskov Mosgaard Mette M Manfroni Giorgio G Singh Petersen Ritika R Hagner Nielsen Line L Müllertz Anette A Boisen Anja A Sylvest Keller Stephan S
Polymers 20191107 11
Microfabricated devices have been introduced as a promising approach to overcome some of the challenges related to oral administration of drugs and, thereby, improve their oral bioavailability. In this study, we fabricate biodegradable microcontainers with different polymers, namely poly-ɛ-caprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA) 50:50 and PLGA 75:25 by hot punching. The mucoadhesion of the microcontainers is assessed with an <i>ex vivo</i> retention model on porcine intestinal t ...[more]
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