Physiological activation and deactivation of soluble guanylate cyclase.
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ABSTRACT:
SUBMITTER: Horst BG
PROVIDER: S-EPMC6919197 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Publications
Physiological activation and deactivation of soluble guanylate cyclase.
Horst Benjamin G BG Marletta Michael A MA
Nitric oxide : biology and chemistry 20180425
Soluble guanylate cyclase (sGC) is responsible for transducing the gaseous signaling molecule nitric oxide (NO) into the ubiquitous secondary signaling messenger cyclic guanosine monophosphate in eukaryotic organisms. sGC is exquisitely tuned to respond to low levels of NO, allowing cells to respond to non-toxic levels of NO. In this review, the structure of sGC is discussed in the context of sGC activation and deactivation. The sequence of events in the activation pathway are described into a c ...[more]
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