Mapping spreading depolarisations after traumatic brain injury: a pilot clinical study protocol.

ABSTRACT:

Introduction

Cortical spreading depolarisation (CSD) is characterised by a near-complete loss of the ionic membrane potential of cortical neurons and glia propagating across the cerebral cortex, which generates a transient suppression of spontaneous neuronal activity. CSDs have become a recognised phenomenon that imparts ongoing secondary insults after brain injury. Studies delineating CSD generation and propagation in humans after traumatic brain injury (TBI) are lacking. Therefore, this study aims to determine the feasibility of using a multistrip electrode array to identify CSDs and characterise their propagation in space and time after TBI.

Methods and analysis

This pilot, prospective observational study will enrol patients with TBI requiring therapeutic craniotomy or cr

SUBMITTER: Cramer SW 

PROVIDER: S-EPMC9280885 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature