Ontology highlight
ABSTRACT:
SUBMITTER: Haruwaka K
PROVIDER: S-EPMC6925219 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Haruwaka Koichiro K Ikegami Ako A Tachibana Yoshihisa Y Ohno Nobuhiko N Konishi Hiroyuki H Hashimoto Akari A Matsumoto Mami M Kato Daisuke D Ono Riho R Kiyama Hiroshi H Moorhouse Andrew J AJ Nabekura Junichi J Wake Hiroaki H
Nature communications 20191220 1
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood-brain barrier (BBB) integrity in this process remains unclear. Using simultaneous in vivo imaging, we demonstrated that systemic inflammation induces CCR5-dependent migration of brain resident microglia to the cerebral vasculature. Vessel-associated microglia initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 and make physi ...[more]