Ontology highlight
ABSTRACT:
SUBMITTER: Harde E
PROVIDER: S-EPMC6927743 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Harde Eva E Nicholson LaShae L Furones Cuadrado Beatriz B Bissen Diane D Wigge Sylvia S Urban Severino S Segarra Marta M Ruiz de Almodóvar Carmen C Acker-Palmer Amparo A
eLife 20191223
Vascular endothelial growth factor (VEGF) is an angiogenic factor that play important roles in the nervous system, although it is still unclear which receptors transduce those signals in neurons. Here, we show that in the developing hippocampus VEGFR2 (also known as KDR or FLK1) is expressed specifically in the CA3 region and it is required for dendritic arborization and spine morphogenesis in hippocampal neurons. Mice lacking VEGFR2 in neurons (<i>Nes-cre Kdr<sup>lox/-</sup></i>) show decreased ...[more]