Ontology highlight
ABSTRACT:
SUBMITTER: Juliar BA
PROVIDER: S-EPMC6930336 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Juliar Benjamin A BA Beamish Jeffrey A JA Busch Megan E ME Cleveland David S DS Nimmagadda Likitha L Putnam Andrew J AJ
Biomaterials 20191118
There is a critical need for biomaterials that support robust neovascularization for a wide-range of clinical applications. Here we report how cells alter tissue-level mechanical properties during capillary morphogenesis using a model of endothelial-stromal cell co-culture within poly(ethylene glycol) (PEG) based hydrogels. After a week of culture, we observed substantial stiffening in hydrogels with very soft initial properties. Endothelial cells or stromal cells alone, however, failed to induc ...[more]