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Prevalence of hyperfiltration among US youth/young adults with overweight and obesity: A population-based association study.

ABSTRACT: Objective:Determine prevalence of hyperfiltration (high estimated glomerular filtration rate "eGFR" >95th percentile for age/sex) among youth and association with BMI classification. Methods:With the use of 1999 to 2016 National Health and Nutrition Examination Survey data from 12- to 29-year-olds, data for serum creatinine and thresholds for high eGFR were normed using a metabolically healthy subsample (no albuminuria, healthy weights, normal blood pressures, blood glucoses, lipids, and liver enzymes). Logistic regression examined the association of BMI classification (healthy weight, overweight, and obesity classes 1-3) with hyperfiltration (eGFR > 95th percentile for age/sex), adjusted for diabetes and other covariates. Results:Of 12- to 29-year-olds (N = 18 698), 27.4% (n = 5493) met criteria for entry into the "healthy subsample" and contributed data to derive normative values for serum creatinine/hyperfiltration thresholds. In the full sample, hyperfiltration prevalence in 12- to 29-year-olds classified as healthy-weight, overweight, and obesity classes 1 to 3 was 4.9%, 4.7%, 6.5%, 8.7%, and 11.8%, respectively (P < .001). In multivariable analysis, obesity classes 2 and 3 were associated with greater likelihood of hyperfiltration (adjusted ORs for class 2: 1.5, 95% CI, 1.1-2.1; and for class 3, 2.1, 95% CI, 1.5-2.9). Diabetes also was associated with hyperfiltration (AOR, 4.0; 95% CI, 2.2-7.4). Conclusion:Obesity classes 2 to 3 are associated with hyperfiltration in youth. Age/sex-specific norms for creatinine and hyperfiltration thresholds may aid recognition of kidney dysfunction early.

SUBMITTER: Turer CB

PROVIDER: S-EPMC6934429 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Prevalence of hyperfiltration among US youth/young adults with overweight and obesity: A population-based association study.

Turer Christy B CB Baum Michel M Dubourg Laurence L Selistre Luciano S LS Skinner Asheley C AC

Obesity science & practice 20190822 6

<h4>Objective</h4>Determine prevalence of hyperfiltration (high estimated glomerular filtration rate "<i>e</i>GFR" >95th percentile for age/sex) among youth and association with BMI classification.<h4>Methods</h4>With the use of 1999 to 2016 National Health and Nutrition Examination Survey data from 12- to 29-year-olds, data for serum creatinine and thresholds for high <i>e</i>GFR were normed using a metabolically healthy subsample (no albuminuria, healthy weights, normal blood pressures, blood ...[more]

PMID: 31890248

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Project description:Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ?1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.From two large Danish cohorts we selected all extremely overweight young men and women (n?=?2,633), and equal numbers of population-based controls (n?=?2,740, drawn randomly from the same populations as the extremes, representing ?212,000 individuals). We followed up novel (at the time of the study) association signals (p<0.001) from the discovery cohort in a genome-wide study of 5,846 Europeans, before attempting to replicate the most strongly associated 28 SNPs in an independent sample of Danish individuals (n?=?20,917) and a population-based cohort of 15-year-old British adolescents (n?=?2,418). Our discovery analysis identified SNPs at three loci known to be associated with BMI with genome-wide confidence (P<5×10(-8); FTO, MC4R and FAIM2). We also found strong evidence of association at the known TMEM18, GNPDA2, SEC16B, TFAP2B, SH2B1 and KCTD15 loci (p<0.001), and nominal association (p<0.05) at a further 8 loci known to be associated with BMI. However, meta-analyses of our discovery and replication cohorts identified no novel associations.Our results indicate that the detectable genetic variation associated with extreme overweight is very similar to that previously found for general BMI. This suggests that population-based study designs with enriched sampling of individuals with the extreme phenotype may be an efficient method for identifying common variants that influence quantitative traits and a valid alternative to genotyping all individuals in large population-based studies, which may require tens of thousands of subjects to achieve similar power.

Dataset Information

Prevalence of hyperfiltration among US youth/young adults with overweight and obesity: A population-based association study.

Publications

Prevalence of hyperfiltration among US youth/young adults with overweight and obesity: A population-based association study.

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