Ontology highlight
ABSTRACT:
SUBMITTER: Shyian M
PROVIDER: S-EPMC6938670 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Shyian Maksym M Albert Benjamin B Zupan Andreja Moset AM Ivanitsa Vitalii V Charbonnet Gabriel G Dilg Daniel D Shore David D
Genes & development 20191205 1-2
Replication forks temporarily or terminally pause at hundreds of hard-to-replicate regions around the genome. A conserved pair of budding yeast replisome components Tof1-Csm3 (fission yeast Swi1-Swi3 and human TIMELESS-TIPIN) act as a "molecular brake" and promote fork slowdown at proteinaceous replication fork barriers (RFBs), while the accessory helicase Rrm3 assists the replisome in removing protein obstacles. Here we show that the Tof1-Csm3 complex promotes fork pausing independently of Rrm3 ...[more]