Ontology highlight
ABSTRACT:
SUBMITTER: Floyd JA
PROVIDER: S-EPMC6941220 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Floyd J Alaina JA Shaver Jeremy M JM Gillespie Alison J AJ Park Unjy U Rogers Richard S RS Nightlinger Nancy S NS Ogata Yuko Y James Jeffrey J JJ Kerwin Bruce A BA
Journal of pharmaceutical sciences 20191025 1
Formulation screening for biotherapeutics can cover a vast array of excipients and stress conditions. These studies consume quantities of limited material and, with higher concentrated therapeutics, more material is needed. Here, we evaluate the use of crystal zenith (CZ) microtiter plates in conjunction with FluoroTec-coated butyl rubber mats as a small-volume, high-throughput system for formulation stability studies. The system was studied for evaporation, edge effects, and stability with comp ...[more]