Dataset Information

Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China.

ABSTRACT:

Background

Oral Epstein-Barr virus (EBV) status reflects host EBV activity and potentially links to EBV-associated diseases, however, factors influencing oral EBV loads or reactivation, such as environmental exposures or host factors, are not fully understood.

Methods

A 2-stage, multicenter, cross-sectional study of 6558 subjects from 21 administrative cities of southern China and 3 populations from representative geographical areas in China (referred to as the south, north, and northeastern populations) was performed. The relationships between demographical factors and environmental exposures to EBV loads were analyzed by logistic regression models.

Results

Current smoking, with a dose-response effect, was found to be strongly associated with higher oral EBV loads in the pooled data, with an odds ratio of 1.58 (95% confidence interval, 1.39-1.79), as well as in each of the separate populations. The odds ratio increased to 3.06 when current smokers in southern China were compared to never smokers in northern China. Additionally, higher oral EBV loads tended to be detected in older participants, male participants, and participants in southern China.

Conclusions

This study provided evidence linking the effect of host-environmental factors, particularly smoking, to oral EBV activity. It could strengthen our understanding of the possible causal roles of EBV-related diseases, which may help to prevent or mitigate EBV-associated diseases.

SUBMITTER: He YQ

PROVIDER: S-EPMC6941616 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China.

He Yong-Qiao YQ Liao Xiao-Yu XY Xue Wen-Qiong WQ Xu Ya-Fei YF Xu Feng-Hua FH Li Fang-Fang FF Li Xi-Zhao XZ Zhang Jiang-Bo JB Wang Tong-Min TM Wang Fang F Yu Huan-Lin HL Feng Qi-Sheng QS Chen Li-Zhen LZ Cao Su-Mei SM Liu Qing Q Mu Jianbing J Jia Wei-Hua WH

The Journal of infectious diseases 20190101 3

<h4>Background</h4>Oral Epstein-Barr virus (EBV) status reflects host EBV activity and potentially links to EBV-associated diseases, however, factors influencing oral EBV loads or reactivation, such as environmental exposures or host factors, are not fully understood.<h4>Methods</h4>A 2-stage, multicenter, cross-sectional study of 6558 subjects from 21 administrative cities of southern China and 3 populations from representative geographical areas in China (referred to as the south, north, and n ...[more]

PMID: 30307559

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Dataset Information

Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China.

Background

Methods

Results

Conclusions

Publications

Association Between Environmental Factors and Oral Epstein-Barr Virus DNA Loads: A Multicenter Cross-sectional Study in China.

Similar Datasets

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