Ontology highlight
ABSTRACT:
SUBMITTER: Brash JT
PROVIDER: S-EPMC6948769 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Brash James T JT Denti Laura L Ruhrberg Christiana C Bucher Franziska F
JCI insight 20191101 21
Vascular endothelial growth factor A (VEGF) induces angiogenesis and vascular hyperpermeability in ocular tissues and is therefore a key therapeutic target for eye conditions in which these processes are dysregulated. In contrast, the therapeutic potential of VEGF's neurotrophic roles in the eye has remained unexploited. In particular, it is not known whether modulating levels of any of the 3 major alternatively spliced VEGF isoforms might provide a therapeutic approach to promote neural health ...[more]