Ontology highlight
ABSTRACT:
SUBMITTER: Bedont JL
PROVIDER: S-EPMC4254772 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Bedont Joseph L JL LeGates Tara A TA Slat Emily A EA Byerly Mardi S MS Wang Hong H Hu Jianfei J Rupp Alan C AC Qian Jiang J Wong G William GW Herzog Erik D ED Hattar Samer S Blackshaw Seth S
Cell reports 20140424 3
Vertebrate circadian rhythms are organized by the hypothalamic suprachiasmatic nucleus (SCN). Despite its physiological importance, SCN development is poorly understood. Here, we show that Lim homeodomain transcription factor 1 (Lhx1) is essential for terminal differentiation and function of the SCN. Deletion of Lhx1 in the developing SCN results in loss of SCN-enriched neuropeptides involved in synchronization and coupling to downstream oscillators, among other aspects of circadian function. In ...[more]