The metabolic regulator mTORC1 controls terminal myeloid differentiation
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ABSTRACT: Monocytes are derived from hematopoietic stem cells through a series of intermediate progenitor stages, but the factors that regulate this process are incompletely defined. Using a Ccr2/Cx3cr1 dual-reporter system to model murine monocyte ontogeny, we conducted a small molecule screen that identified an essential role of mechanistic target of rapamycin complex 1 (mTORC1) in the development of monocytes and other myeloid cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE96607 | GEO | 2017/05/01
SECONDARY ACCESSION(S): PRJNA379153
REPOSITORIES: GEO
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