Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population.

ABSTRACT: Consanguineous populations of the Arabian Peninsula, which has seen an uncontrolled rise in type 2 diabetes incidence, are underrepresented in global studies on diabetes genetics. We performed a genome-wide association study on the quantitative trait of fasting plasma glucose (FPG) in unrelated Arab individuals from Kuwait (discovery-cohort:n?=?1,353; replication-cohort:n?=?1,196). Genome-wide genotyping in discovery phase was performed for 632,375 markers from Illumina HumanOmniExpress Beadchip; and top-associating markers were replicated using candidate genotyping. Genetic models based on additive and recessive transmission modes were used in statistical tests for associations in discovery phase, replication phase, and meta-analysis that combines data from both the phases. A genome-wide significant association with high FPG was found at rs1002487 (RPS6KA1) (p-discovery?=?1.64E-08, p-replication?=?3.71E-04, p-combined?=?5.72E-11; ?-discovery?=?8.315; ?-replication?=?3.442; ?-combined?=?6.551). Further, three suggestive associations (p-values?

SUBMITTER: Hebbar P 

PROVIDER: S-EPMC6957513 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature