Unknown

Dataset Information

0

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

ABSTRACT: Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

SUBMITTER: Hwang JY 

PROVIDER: S-EPMC4274808 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

Hwang Joo-Yeon JY   Sim Xueling X   Wu Ying Y   Liang Jun J   Tabara Yasuharu Y   Hu Cheng C   Hara Kazuo K   Tam Claudia H T CH   Cai Qiuyin Q   Zhao Qi Q   Jee Sunha S   Takeuchi Fumihiko F   Go Min Jin MJ   Ong Rick Twee Hee RT   Ohkubo Takayoshi T   Kim Young Jin YJ   Zhang Rong R   Yamauchi Toshimasa T   So Wing Yee WY   Long Jirong J   Gu Dongfeng D   Lee Nanette R NR   Kim Soriul S   Katsuya Tomohiro T   Oh Ji Hee JH   Liu Jianjun J   Umemura Satoshi S   Kim Yeon-Jung YJ   Jiang Feng F   Maeda Shiro S   Chan Juliana C N JC   Lu Wei W   Hixson James E JE   Adair Linda S LS   Jung Keum Ji KJ   Nabika Toru T   Bae Jae-Bum JB   Lee Mi Hee MH   Seielstad Mark M   Young Terri L TL   Teo Yik Ying YY   Kita Yoshikuni Y   Takashima Naoyuki N   Osawa Haruhiko H   Lee So-Hyun SH   Shin Min-Ho MH   Shin Dong Hoon DH   Choi Bo Youl BY   Shi Jiajun J   Gao Yu-Tang YT   Xiang Yong-Bing YB   Zheng Wei W   Kato Norihiro N   Yoon Miwuk M   He Jiang J   Shu Xiao Ou XO   Ma Ronald C W RC   Kadowaki Takashi T   Jia Weiping W   Miki Tetsuro T   Qi Lu L   Tai E Shyong ES   Mohlke Karen L KL   Han Bok-Ghee BG   Cho Yoon Shin YS   Kim Bong-Jo BJ  

Diabetes 20140903 1

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to a  ...[more]

Similar Datasets

Unknown Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
| S-EPMC3158568 | biostudies-literature
Unknown Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
| S-EPMC4351379 | biostudies-literature
Unknown Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population.
| S-EPMC6957513 | biostudies-literature
Unknown Meta-analysis identifies common variants associated with body mass index in east Asians.
| S-EPMC3288728 | biostudies-literature
Unknown Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.
| S-EPMC3582398 | biostudies-literature
Unknown Meta-analysis of genome-wide association studies identifies three novel loci for saturated fatty acids in East Asians.
| S-EPMC5374030 | biostudies-literature
Unknown Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
| S-EPMC3285588 | biostudies-literature
Unknown Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
| S-EPMC5179918 | biostudies-literature
Unknown A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.
| S-EPMC3900106 | biostudies-literature
Unknown Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.
| S-EPMC5704911 | biostudies-literature