Ontology highlight
ABSTRACT:
SUBMITTER: Polykretis P
PROVIDER: S-EPMC6957824 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Polykretis Panagis P Luchinat Enrico E Boscaro Francesca F Banci Lucia L
Redox biology 20200107
Methylglyoxal (MG) is a highly reactive aldehyde spontaneously formed in human cells mainly as a by-product of glycolysis. Such endogenous metabolite reacts with proteins, nucleotides and lipids forming advanced glycation end-products (AGEs). MG binds to arginine, lysine and cysteine residues of proteins causing the formation of stable adducts that can interfere with protein function. Among the proteins affected by glycation, MG has been found to react with superoxide dismutase 1 (SOD1), a funda ...[more]