Ontology highlight
ABSTRACT:
SUBMITTER: Zhang YK
PROVIDER: S-EPMC6961461 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20191201 1
Identification of pheromone receptors plays a central role for uncovering signaling pathways that underlie chemical communication in animals. Here, we describe the synthesis and bioactivity of photoaffinity probes for the ascaroside ascr#8, a sex-pheromone of the model nematode, Caenorhabditis elegans. Structure-activity studies guided incorporation of alkyne- and diazirine-moieties and revealed that addition of functionality in the sidechain of ascr#8 was well tolerated, whereas modifications t ...[more]