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Next-Generation Whole-Cell Pneumococcal Vaccine.

ABSTRACT: Streptococcus pneumoniae remains a major public health hazard. Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal diseases, there is still a need for new vaccines with unlimited serotype coverage, long-lasting protection, and lower cost to be developed. One of the most promising candidates is the Whole-Cell Pneumococcal Vaccine (WCV). The new generation of whole-cell vaccines is based on an unencapsulated serotype that allows the expression of many bacterial antigens at a lower cost than a recombinant vaccine. These vaccines have been extensively studied, are currently in human trial phase 1/2, and seem to be the best treatment choice for pneumococcal diseases, especially for developing countries.

SUBMITTER: Morais V

PROVIDER: S-EPMC6963273 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Next-Generation Whole-Cell Pneumococcal Vaccine.

Morais Victor V Texeira Esther E Suarez Norma N

Vaccines 20191016 4

<i>Streptococcus pneumoniae</i> remains a major public health hazard. Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal diseases, there is still a need for new vaccines with unlimited serotype coverage, long-lasting protection, and lower cost to be developed. One of the most promising candidates is the Whole-Cell Pneumococcal Vaccine (WCV). The new generation of whole-cell vaccines is based on an unencapsulated serotype ...[more]

PMID: 31623286

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