Ontology highlight
ABSTRACT:
SUBMITTER: Parackova Z
PROVIDER: S-EPMC6965661 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Parackova Z Z Vrabcova P P Zentsova I I Kayserova J J Richtrova I I Sojka L L Stechova K K Sumnik Z Z Sediva A A
Scientific reports 20200116 1
Interleukin 27 (IL-27), a member of the IL-12 family, is important for T cell differentiation; however, little is known about its effect on dendritic cells (DCs). IL-27 can activate multiple signaling cascades, including the JAK/STAT pathway, and depending on the setting it can both promote and antagonize inflammatory responses. An anti-inflammatory function of IL-27 has been reported in several autoimmune diseases; however, in type 1 diabetes (T1D), an autoimmune disease where autoreactive cyto ...[more]