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Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model.


ABSTRACT: The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.

SUBMITTER: De Giovanni C 

PROVIDER: S-EPMC6966465 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model.

De Giovanni Carla C   Nicoletti Giordano G   Landuzzi Lorena L   Palladini Arianna A   Lollini Pier-Luigi PL   Nanni Patrizia P  

Cancers 20191127 12


The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer. ...[more]

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