Ontology highlight
ABSTRACT:
SUBMITTER: Noonan JJ
PROVIDER: S-EPMC6966586 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Noonan Janis J JJ Jarzabek Monika M Lincoln Frank A FA Cavanagh Brenton L BL Pariag Arhona R AR Juric Viktorija V Young Leonie S LS Ligon Keith L KL Jahns Hanne H Zheleva Daniella D Prehn Jochen H M JHM Rehm Markus M Byrne Annette T AT Murphy Brona M BM
Cancers 20191212 12
Glioblastoma (GBM) is the most common primary brain tumor with no available cure. As previously described, seliciclib, a first-generation cyclin-dependent kinase (CDK) inhibitor, down-regulates the anti-apoptotic protein, Mcl-1, in GBM, thereby sensitizing GBM cells to the apoptosis-inducing effects of the death receptor ligand, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Here, we have assessed the efficacy of seliciclib when delivered in combination with the antibody agains ...[more]