Ontology highlight
ABSTRACT:
SUBMITTER: Fornari F
PROVIDER: S-EPMC6966618 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Fornari Francesca F Gramantieri Laura L Callegari Elisa E Shankaraiah Ram C RC Piscaglia Fabio F Negrini Massimo M Giovannini Catia C
Cancers 20191201 12
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Molecular heterogeneity and absence of biomarkers for patient allocation to the best therapeutic option contribute to poor prognosis of advanced stages. Aberrant microRNA (miRNA) expression is associated with HCC development and progression and influences drug resistance. Therefore, miRNAs have been assayed as putative biomarkers and therapeutic targets. MiRNA-based therapeutic approaches demonstrated safety ...[more]