Ontology highlight
ABSTRACT:
SUBMITTER: Laothamatas I
PROVIDER: S-EPMC6969540 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Laothamatas Isara I Gao Peng P Wickramaratne Anushka A Quintanilla Carlo G CG Dino Arianna A Khan Crystal A CA Liou Jen J Green Carla B CB
Proceedings of the National Academy of Sciences of the United States of America 20191226 2
An intimate link exists between circadian clocks and metabolism with nearly every metabolic pathway in the mammalian liver under circadian control. Circadian regulation of metabolism is largely driven by rhythmic transcriptional activation of clock-controlled genes. Among these output genes, <i>Nocturnin</i> (<i>Noct</i>) has one of the highest amplitude rhythms at the mRNA level. The <i>Noct</i> gene encodes a protein (NOC) that is highly conserved with the endonuclease/exonuclease/phosphatase ...[more]