Unknown

Dataset Information

0

Core transcriptional regulatory circuits in prion diseases.


ABSTRACT: Complex diseases involve dynamic perturbations of pathophysiological processes during disease progression. Transcriptional programs underlying such perturbations are unknown in many diseases. Here, we present core transcriptional regulatory circuits underlying early and late perturbations in prion disease. We first identified cellular processes perturbed early and late using time-course gene expression data from three prion-infected mouse strains. We then built a transcriptional regulatory network (TRN) describing regulation of early and late processes. We found over-represented feed-forward loops (FFLs) comprising transcription factor (TF) pairs and target genes in the TRN. Using gene expression data of brain cell types, we further selected active FFLs where TF pairs and target genes were expressed in the same cell type and showed correlated temporal expression changes in the brain. We finally determined core transcriptional regulatory circuits by combining these active FFLs. These circuits provide insights into transcriptional programs for early and late pathophysiological processes in prion disease.

SUBMITTER: Kim TK 

PROVIDER: S-EPMC6972013 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Core transcriptional regulatory circuits in prion diseases.

Kim Taek-Kyun TK   Lee Inyoul I   Cho Ji-Hoon JH   Canine Brenda B   Keller Andrew A   Price Nathan D ND   Hwang Daehee D   Carlson George G   Hood Leroy L  

Molecular brain 20200120 1


Complex diseases involve dynamic perturbations of pathophysiological processes during disease progression. Transcriptional programs underlying such perturbations are unknown in many diseases. Here, we present core transcriptional regulatory circuits underlying early and late perturbations in prion disease. We first identified cellular processes perturbed early and late using time-course gene expression data from three prion-infected mouse strains. We then built a transcriptional regulatory netwo  ...[more]

Similar Datasets

| S-EPMC7581508 | biostudies-literature
| S-EPMC4772020 | biostudies-literature
| S-EPMC1681491 | biostudies-literature
| S-EPMC4967716 | biostudies-literature
| S-EPMC3006442 | biostudies-literature
| S-EPMC9485839 | biostudies-literature
| S-EPMC8482286 | biostudies-literature
| S-EPMC10445752 | biostudies-literature
| S-EPMC10103937 | biostudies-literature
| S-EPMC2268660 | biostudies-literature