Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC6972586 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191119 1
We report herein the catalytic triboration of terminal alkynes with B<sub>2</sub> pin<sub>2</sub> (bis(pinacolato)diboron) using readily available Cu(OAc)<sub>2</sub> and P<sup>n</sup> Bu<sub>3</sub> . Various 1,1,2-triborylalkenes, a class of compounds that have been demonstrated to be potential matrix metalloproteinase (MMP-2) inhibitors, were obtained directly in moderate to good yields. The process features mild reaction conditions, a broad substrate scope, and good functional group toleranc ...[more]