Dataset Information

Mg(OH)₂ -Facilitated Liquid-Phase Conversion of Lactic Acid into 1,2-Propanediol over Cu: An Experimental and Theoretical Study.

ABSTRACT: Mg(OH)₂ is found to exhibit superior performance in the liquid-phase conversion of lactic acid (LA) into 1,2-propanediol over Cu. A conversion of 90?% with a selectivity of 98?% is achieved at 513?K and 5?MPa H₂ . Mg(LA)₂ could be identified as a crucial intermediate in this reaction, as it undergoes faster conversion than the combination of LA and Mg(OH₂ ) and regeneration of Mg(OH)₂ through the conversion of Mg(LA)₂ as a substrate. DFT calculations reveal that the energetic span of the reaction decreases from 46.6?kcal?mol^-1 catalyzed with no cation to 43.6?kcal?mol^-1 with [Mg(OH)]⁺ , confirming the facilitating effect of Mg(OH)₂ .

SUBMITTER: Wang X

PROVIDER: S-EPMC6973064 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Publications

Mg(OH)2 -Facilitated Liquid-Phase Conversion of Lactic Acid into 1,2-Propanediol over Cu: An Experimental and Theoretical Study.

Wang Xinde X Beine Anna Katharina AK Hausoul Peter J C PJC Palkovits Regina R

ChemSusChem 20191021 1

Mg(OH)2 is found to exhibit superior performance in the liquid-phase conversion of lactic acid (LA) into 1,2-propanediol over Cu. A conversion of 90 % with a selectivity of 98 % is achieved at 513 K and 5 MPa H2 . Mg(LA)2 could be identified as a crucial intermediate in this reaction, as it undergoes faster conversion than the combination of LA and Mg(OH2 ) and regeneration of Mg(OH)2 through the conversion of Mg(LA)2 as a substra ...[more]

PMID: 31592572

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Project description:BACKGROUND: The modern society primarily relies on petroleum and natural gas for the production of fuels and chemicals. One of the major commodity chemicals 1,2-propanediol (1,2-PDO), which has an annual production of more than 0.5 million tons in the United States, is currently produced by chemical processes from petroleum derived propylene oxide, which is energy intensive and not sustainable. In this study, we sought to achieve photosynthetic production of 1,2-PDO from CO2 using a genetically engineered cyanobacterium Synechococcus elongatus PCC 7942. Compared to the previously reported biological 1,2-PDO production processes which used sugar or glycerol as the substrates, direct chemical production from CO2 in photosynthetic organisms recycles the atmospheric CO2 and will not compete with food crops for arable land. RESULTS: In this study, we reported photosynthetic production of 1,2-PDO from CO2 using a genetically engineered cyanobacterium Synechococcus elongatus PCC 7942. Introduction of the genes encoding methylglyoxal synthase (mgsA), glycerol dehydrogenase (gldA), and aldehyde reductase (yqhD) resulted in the production of ~22 mg/L 1,2-PDO from CO2. However, a comparable amount of the pathway intermediate acetol was also produced, especially during the stationary phase. The production of 1,2-PDO requires a robust input of reducing equivalents from cellular metabolism. To take advantage of cyanobacteria's NADPH pool, the synthetic pathway of 1,2-PDO was engineered to be NADPH-dependent by exploiting the NADPH-specific secondary alcohol dehydrogenases which have not been reported for 1,2-PDO production previously. This optimization strategy resulted in the production of ~150 mg/L 1,2-PDO and minimized the accumulation of the incomplete reduction product, acetol. CONCLUSION: This work demonstrated that cyanobacteria can be engineered as a catalyst for the photosynthetic conversion of CO2 to 1,2-PDO. This work also characterized two NADPH-dependent sADHs for their catalytic capacity in 1,2-PDO formation, and suggested that they may be useful tools for renewable production of reduced chemicals in photosynthetic organisms.

Dataset Information

Mg(OH)₂ -Facilitated Liquid-Phase Conversion of Lactic Acid into 1,2-Propanediol over Cu: An Experimental and Theoretical Study.

Publications

Mg(OH)<sub>2</sub> -Facilitated Liquid-Phase Conversion of Lactic Acid into 1,2-Propanediol over Cu: An Experimental and Theoretical Study.

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