Ontology highlight
ABSTRACT:
SUBMITTER: Hassan IS
PROVIDER: S-EPMC6980373 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20190313 12
Reliable design of artificial metalloenzymes (ArMs) to access transformations not observed in nature remains a long-standing and important challenge. We report that a monomeric streptavidin (mSav) Rh(III) ArM permits asymmetric synthesis of α,β-unsaturated-δ-lactams via a tandem C-H activation and [4+2] annulation reaction. These products are readily derivatized to enantioenriched piperidines, the most common N-heterocycle found in FDA approved pharmaceuticals. Desired δ-lactams are achieved in ...[more]