Ontology highlight
ABSTRACT:
SUBMITTER: Federizon J
PROVIDER: S-EPMC6980772 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Federizon Jasmin J Frye Amber A Huang Wei-Chiao WC Hart Thomas M TM He Xuedan X Beltran Christopher C Marcinkiewicz Ashley L AL Mainprize Iain L IL Wills Melanie K B MKB Lin Yi-Pin YP Lovell Jonathan F JF
Vaccine 20191111 4
Outer surface protein A (OspA) is a Borrelia lipoprotein and an established Lyme disease vaccine target. Admixing non-lipidated, recombinant B. burgdorferi OspA with liposomes containing cobalt porphyrin-phospholipid (CoPoP) resulted in rapid, particulate surface display of the conformationally intact antigen. Particleization was serum-stable and led to enhanced antigen uptake in murine macrophages in vitro. Mouse immunization using CoPoP liposomes that also contained a synthetic monophosphoryl ...[more]