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Porphyrin-phospholipid liposomes with tunable leakiness.

ABSTRACT: Drug bioavailability is a key consideration for drug delivery systems. When loaded with doxorubicin, liposomes containing 5 molar % porphyrin-phospholipid (HPPH liposomes) exhibited in vitro and in vivo serum stability that could be fine-tuned by varying the drug-to-lipid ratio. A higher drug loading ratio destabilized the liposomes, in contrast to standard liposomes which displayed an opposite and less pronounced trend. Following systemic administration of HPPH liposomes, near infrared laser irradiation induced vascular photodynamic damage, resulting in enhanced liposomal doxorubicin accumulation in tumors. In laser-irradiated tumors, the use of leaky HPPH liposomes resulted in improved doxorubicin bioavailability compared to stable standard liposomes. Using this approach, a single photo-treatment with 10mg/kg doxorubicin rapidly eradicated tumors in athymic nude mice bearing KB or MIA Paca-2 xenografts.

SUBMITTER: Luo D

PROVIDER: S-EPMC4688124 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Porphyrin-phospholipid liposomes with tunable leakiness.

Luo Dandan D Carter Kevin A KA Razi Aida A Geng Jumin J Shao Shuai S Lin Cuiyan C Ortega Joaquin J Lovell Jonathan F JF

Journal of controlled release : official journal of the Controlled Release Society 20151111 Pt A

Drug bioavailability is a key consideration for drug delivery systems. When loaded with doxorubicin, liposomes containing 5 molar % porphyrin-phospholipid (HPPH liposomes) exhibited in vitro and in vivo serum stability that could be fine-tuned by varying the drug-to-lipid ratio. A higher drug loading ratio destabilized the liposomes, in contrast to standard liposomes which displayed an opposite and less pronounced trend. Following systemic administration of HPPH liposomes, near infrared laser ir ...[more]

PMID: 26578438

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