Ontology highlight
ABSTRACT:
SUBMITTER: Carter KA
PROVIDER: S-EPMC6247800 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Molecular pharmaceutics 20151231 2
Liposomes incorporating porphyrin-phospholipid (PoP) can be formulated to release entrapped contents in response to near-infrared (NIR) laser irradiation. Here, we examine effects of chelating copper or zinc into the PoP. Cu(II) and Zn(II) PoP liposomes, containing 10 molar % HPPH-lipid, exhibited unique photophysical properties and released entrapped cargo in response to NIR light. Cu-PoP liposomes exhibited minimal fluorescence and reduced production of reactive oxygen species upon irradiation ...[more]